Octacalcium Phosphate Bone Substitute (Bontree®): From Basic Research to Clinical Case Study

Bone grafts used in alveolar bone regeneration can be categorized into autografts, allografts, xenografts, and synthetic bones, depending on their origin. The purpose of this study was to evaluate the effect a commercialized octacalcium phosphate (OCP)-based substitute material (Bontree®) vitro, vivo, clinical cases. Material characterization Bontree® granules (0.5 mm 1.0 mm) using scanning electron microscopy X-ray diffraction showed that both 0.5 were uniformly composed mainly OCP. receptor activator NF-κB ligand (RANKL) alkaline phosphatase (ALP) activities MG63 cells assessed compare with commercial biphasic calcium ceramic (MBCP+TM). Compared MBCP+TM, suppressed RANKL increased ALP activity. A rabbit tibia model examine effects granule size had higher new formation ability than granules. Three cases for ridge or sinus augmentation are described. All eight implants three patients 100% success rate after 1 year functional loading. This basic research application demonstrated safety efficacy regeneration.